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Product Group

ELISA tests for the diagnosis of infectious diseases

ELISA Test zur Diagnose einer latenten Tuberkulose-Infektion

Positive control  for immunoassays of the SERION ELISA classic product line.

Control sample pairs for determination of the antibody index

Lyophilized positive control sera for qualitative antibody determination

Control samples for internal quality assurance and guideline compliant practice

Determination of the antibody index (AI) for the detection of intrathecal synthesized antibodies 

Serological detection of antibodies against human pathogens according to the KOLMER technique

Reagent

SERION Avidity Reagents are complementary components which, in combination with the corresponding SERION ELISA classic, enable the avidity determination of pathogen specific IgG antibodies.

For a precise pathogen-specific IgM antibody detection it is necessary to pretreat serum samples with rheumatoid factor (Rf)-Absorbent. SERION Rf-Absorbent precipitates up to 15 mg IgG / ml from undiluted serum.

Pathogen

A variety of bacteria are responsible to some extent for serious infectious diseases. The first diagnosis of a bacterial infection is usually based on clinical symptoms. Commonly, laboratory diagnostics are used to determine the exact pathogen, as the rapid identification of the causative agent is significantly decisive in determining the appropriate therapy.

Viral infections can cause a variety of diseases with a high diversity of clinical symptoms. The pathogen specific diagnosis of a viral disease is carried out by laboratory diagnostics and is supported by serological methods.

Parasitic infections in humans are caused by eukaryotic unicellular Protozoa (including Leishmania and Toxoplasma) and multicellular Metazoa (including tapeworms). Without treatment these infections can lead to clinically manifested damage. The diagnosis is supported by serological methods

Infections with human pathogenic fungi affect, in particular nails, skin and mucous membranes. In at risk patients with reduced immunity these infections often lead to life-threatening invasive mycoses. The most common systemic infections are i.a. caused by Aspergillus fumigatus and Candida albicans.

Diagnostic Category

Children`s diseases or “childhood illness” are usually relatively harmless. However severe complications are also associated to them. The risk of damaging effects can be significantly reduced by a fast pathogen specific diagnosis and timely therapeutic intervention.

The demonstration of antibodies against fungi of the genera Aspergillus and Candida combined with the identification of specific pathogenic antigens is particularly suited to the monitoring of at risk patients. By measuring levels of individual immunoglobulin classes in serial blood samples the early diagnosis of invasive mycoses is enhanced..

Due to their structure, Herpes viruses are amongst the most complex and largest known viruses. These pathogens are responsible for a variety of diseases and are capable of infecting and replicating in a wide range of cell types, such as lymphocytes, nerve cells and epidermal cells. Following infection the viruses remain lifelong in the host organism.

The demonstration of antibody levels against various infectious agents during pregnancy facilitates early disease diagnosis and determination of immunity against pathogens which may be harmful to the unborn child. These pathogens are summarized to the so called “extended TORCH panel”.

Gastrointestinal infections are amongst the most common causes of death globally and can be caused by a wide range of different bacteria or viruses. In particular, the quantification of antibody activities of all relevant immunoglobulin classes allows a comparative study of serum pairs for monitoring disease stage and therapy.

Diseases caused by Chlamydia ssp. affect, in particular, the mucous membranes in the eyes, respiratory tract and genital region and can lead to severe consequences. C. trachomatis infection is one of the most common sexually transmitted bacterial diseases, while C. pneumoniae can cause chronic bronchitis or pneumonia and C. psittaci is the cause of ornithosis (Psittacosis).

Determining the immune status is especially important during pregnancy and for vaccination recommendations. Immune protection often correlates with activity levels of IgG antibodies. The quantitative demonstration of IgG antibody activities is used in particular to confirm and monitor vaccination results and for determination of immune status, e.g. during pregnancy.

Infections acquired in utero may have severe consequences for the fetus and newborn child. Within the framework of a screening program, neonatal heel-prick dried blood spot (DBS) samples are tested for specific IgM antibodies to certain infectious agents. This helps to identify infected neonates rapidly and facilitates appropriate medical interventions.

Respiratory tract infections, particularly those of bacterial and viral aetiology, are amongst the most common diseases worldwide. The detection of specific antibodies against a variety of pathogens causing respiratory diseases provides a sensitive identification of acute infections as well as supporting the differential diagnosis in cases of atypical pneumonia.

Tropical diseases are infections that occur exclusively or predominantly in tropical or subtropical climate zones. They are mainly the result of infections by parasites or viruses, less frequently bacteria, which are transmitted by blood-feeding insects, primarily mosquitos. As a consequence of climatic changes and increased travel activities, tropical diseases are becoming more significant in temperate latitudes.

Zoonoses are infections caused by the transmission from infected animals to humans. Bacteria, viruses and parasites are frequent causes of such infections. Due to the wide range of symptoms, diagnosis is generally confirmed by laboratory testing in suspected clinical cases.

Product Group
Order Number
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Avidity Control
BR109AVID
Avidity Reagent
B109AVID
SERION ELISA classic
ESR109G
Avidity Control
BR129AVID
Avidity Reagent
B129AVID
SERION ELISA classic
ESR129G
Avidity Control
BR110AVID
Avidity Reagent
B110AVID
SERION ELISA classic
ESR110G