Reagents for Avidity testing

Determination of Avidity

SERION Avidity Reagents are complementary components which, in combination with the corresponding SERION ELISA classic, enable the avidity of pathogen specific IgG antibodies to be determined. Avidity determinations serve to support the differentiation between acute and past infections which is of particular value within the framework of prenatal serological testing. On request we can supply you with our Microsoft® Excel based software tool SERION avidity which supports the calculation of avidity indices.

Test principle

Avidity testing of IgG antibodies is performed using the respective SERION ELISA classic IgG with the aid of the corresponding SERION ELISA classic Avidity Reagent. The avidity reagent causes the disassociation of low affinity antibody-antigen complexes, formed on the solid phase during the ELISA test performance, whereas high affinity complexes are not affected. Consequently, low affinity antibodies are removed during the following wash steps and a comparison of parallel tests with and without the avidity reagent allows for the determination of the avidity of the antibodies present in a sample.

Products

Cytomegalovirus IgG
SERION ELISA classic
ESR109G
Cytomegalovirus Avidity Reagent
Avidity Reagent
B109AVID
Rubella Virus IgG
SERION ELISA classic
ESR129G
Rubella Virus Avidity Reagent
Avidity Reagent
B129AVID
Toxoplasma gondii IgG
SERION ELISA classic
ESR110G
Toxoplasma gondii Avidity Reagent
Avidity Reagent
B110AVID
Rubella Virus
Avidity Control
BR129AVID
Toxoplasma gondii
Avidity Control
BR110AVID
Cytomegalovirus
Avidity Control
BR109AVID