Enterovirus

The SERION ELISA classic Enterovirus IgA, IgG and IgM tests are qualitative and quantitative immunoassays for the demonstration of human antibodies in serum or plasma directed against Enteroviruses. The detection of different antibody classes allows for the confirmation of contact with the pathogen and supports the categorization of the disease stage. The SERION ELISA classic Enterovirus IgG test is validated for the detection of intrathecally synthesized IgG antibodies in CSF diagnostics.

Highlights

• Use of a mixture of recombinant antigens derived from conserved and subtype-specific epitopes of the VP1 proteins of ECHO virus E6 and E9 as well as Coxsackievirus B1, B3 and B5
• Demonstration of all Serotypes because of the chosen antigen
• Sensitive demonstration of IgM antibodies for detection of primary infections, particularly in children
• IgA and IgG detection for confirmation of acute, chronic and previous infections
• Exclusion of background seroprevalence of IgG antibodies resulting in the specific detection of clinically relevant antibody activities
• Quantification of IgA, IgG and IgM antibodies for disease stage monitoring and therapy control
• Detection of intrathecally synthesized IgG antibodies for CSF Diagnostics